Publications

Manuscripts: 

Saha A*, Zuniga J*, Mian K*, Zhai H, Derr PJ, Hoon M, Sinha R. Regional variation in the organization and connectivity of the first synapse in the primate night vision pathway. iScience  2023 Oct 2;26(11):108113. (*equal contribution) (link)

Wisner SR*, Saha A*, Grimes WN, Mizerska K, Kolarik HJ, Wallin J, Diamond JS, Sinha R, Hoon M. Sensory deprivation arrests cellular and synaptic development of the night vision circuitry in the primate retina. Current Biology 2023 Oct 23;33(20):4415-4429.e3. (*equal contribution) (link)

Saha A, Capowski E, Zepeda M A F, Nelson E C, Gamm D G, Sinha R. Cone photoreceptors in human stem cell-derived retinal organoids demonstrate intrinsic light responses that mimic those of primate fovea. Cell Stem Cell 2022 Mar 03;29(3): 460-471. (link)

Research highlighted in Previews by Angueyra and Li “Video, ergo sum: The search for response to natural light” Cell Stem Cell 2022 Mar 03;29(3): 349-350. (link)

Research highlighted in UW Madison press release. (link)

Sinha R, Grimes W, Ebbinghaus B, Luu K, Cherry T, Rieke F, Rudolph W, Wong, R, Hoon M, Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function. Current Biology. 2021 Aug 19: S0960-9822(21)01049-6. (link)

Nagy J, Ebbinghaus B, Hoon M, Sinha R. GABAA presynaptic inhibition regulates the gain and kinetics of retinal output neurons. eLife 2021;10:e60994 DOI: 10.7554/eLife.60994. (link)

Sawant A, Ebbinghaus BN, Bleckert A, Gamlin C, Yu WQ, Berson D, Rudolph U, Sinha R, Hoon M. Organization and Emergence of a mixed GABA-Glycine retinal circuit that provides inhibition to mouse ON-sustained alpha retinal ganglion cells. Cell Reports, 2021 Mar 16;34(11):108858. (link)

Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Rieke F, Craig AM, Wong RO, Hoon M. LRRTM4: A novel regulator of presynaptic inhibition and ribbon synapse arrangements of retinal bipolar cells. Neuron 2020 Mar 18; 105(6):1007-1017. (link)

Research highlighted in Previews by Peng and Sampath “LRR-ning the rules: Synapse organization in the primary rod pathway” Neuron 2020 Mar 18;105(6):949-951. (link)

Sinha R. Shining light on the mode and mechanism of vesicular release at rod photoreceptor synapse. Biophys J. 2020 Feb 25;118(4):785-787. (link)

Baudin J, Angueyra J, Sinha R*, Rieke F. S cone photoreceptors in the primate retina are functionally distinct from L and M cones. eLife. 2019; 8:e39166. (* corresponding author). (link)

Sinha R*, Hoon M*, Baudin J, Okawa H, Wong RO, Rieke F*. Cellular and Circuit Mechanisms Shaping the Perceptual Properties of the Primate Fovea. Cell. 2017 Jan 26; 168(3):413-426. (*corresponding author). (link)

Research highlighted in Commentary by R.H. Masland “Vision: Two Speeds in the Retina” Current Biology. 2017 Apr 24;27(8):303-305. (link)

Sinha R, Lee A, Rieke F, Haeseleer F. Lack of CaBP1/caldendrin or CaBP2 leads to altered ganglion cell responses. eNeuro Oct 2016, 2016 Oct 28;3(5). (link)

Hoon M, Sinha R, Okawa H, Suzuki SC, Hirano AA, Brecha N, Rieke F, Wong RO. Neurotransmission plays contrasting roles in the maturation of inhibitory synapses on axons and dendrites of retinal bipolar cells. PNAS. 2015 Oct 13; 112(41): 12840-5. (link)

Sinha R, Ahmed S, Jahn R, Klingauf J. Two synaptobrevin molecules are sufficient for vesicle fusion in central nervous system synapses. PNAS. 2011 Aug 23;108(34):14318-23. (link)

Hua Y*, Sinha R*, Thiel CS*, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J. A readily retrievable pool of synaptic vesicles. Nature Neuroscience. 2011 Jun 12;14(7):833-9. (*equal contribution). (link)

Hua Y*, Sinha R*, Martineau M, Kahms M, Klingauf J. A common origin of synaptic vesicles undergoing evoked and spontaneous fusion. Nature Neuroscience. 13, 1451–1453 (2010). (*equal contribution). (link)

Suseendranathan K, Sengupta K, Rikhy R, D’Souza JS, Kokkanti M, Kulkarni MG, Kamdar R, Changede R, Sinha R, Subramanian L, Singh K, Rodrigues V, Rao BJ. Expression pattern of Drosophila translin and behavioral analyses of the mutant. Eur J Cell Biol. 2007 Mar; 86(3):173-86.

Book Chapter: 

Hoon M, Sinha R, Okawa H. Using fluorescent markers to estimate synaptic connectivity in situ. Methods Mol Biol 1538 (2017), Humana Press ISBN 978-1-4939-6688-2.